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Hyaluronsäure in der modernen Medizin
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class="page-template-default page page-id-62 page-parent custom content-shadow responsive pagelines default full_width ">

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Hyaluronsäure kann verschiedene Typen von Bindegewebe schützen und reparieren. Durch ihre Wirkung als Boten- und Signalstoff vermag sie zusätzlich körpereigene Wachstums- und Regenerationsprozesse zu stimulieren. Klassische Anwendungen liegen in Orthopädie und Augenheilkunde. Heute kommt zudem eine Vielzahl von Hyaluronsäure-Präparaten in der Schönheitsmedizin und plastischen Chirurgie zum Einsatz. Interessante Perspektiven eröffnen sich für die Nutzung von Hyaluronsäure bei der Regeneration von Geweben, beispielsweise in der Therapie von chronischen Wunden oder Parodontitis.

Kurzer geschichtlicher Exkurs

Vater der Hyaluronforschung und Pionier diverser therapeutischer Methoden ist Dr. Endre Balazs, ein in Harvard, später an der Columbia-Universität New York forschender ungarischer Mediziner. Balazs hat in den 1960er und 1970er Jahren den therapeutischen Einsatz von Hyaluronsäure in Augenheilkunde und Gelenkmedizin auf den Weg gebracht und Pionierarbeit auf dem Gebiet der Extraktion von Hyaluronsäure aus tierischen Materialien geleistet.

In den 1980er Jahren trug er mit seinem eigenen Unternehmen, Biomatrix Inc., zur Etablierung der Hyaluronsäure in der Biotechnologie bei. Auf Balazs‘ Arbeiten basieren moderne biotechnologische und medizinische Methoden, wie etwa die Nutzung von Hyaluronsäure-Gelen als bioaktives Gerüst beim Design künstlicher Gewebe oder die Verwendung des Biomoleküls als Trägersubstanz zur Applikation von Wirkstoffen.

Hyaluronsäure-Injektionen bei Arthrose und Arthritis

Hyaluronsäure ist einer der Hauptbestandteile der Synovialflüssigkeit. Diese zähe Schmiere wird vom Gelenkknorpel abgesondert und füllt den Gelenkspalt aus. Mit ihrem besonderen viskoelastischen Eigenschaften wirkt sie dort als Stoßdämpfer und sorgt für eine gute, reibungsarme Beweglichkeit der Knochen gegeneinander. Auch dem Knorpel selbst verleiht sein Gehalt an Hyaluronsäure Elastizität.

Patienten, die an den Gelenkerkrankungen Arthritis oder Arthrose leiden, können von der Therapie mit Hyaluronsäure profitieren. Sie lindert Schmerzen, verbessert den Zustand des Knorpels und erhöht die Beweglichkeit geschädigter Gelenke. Dabei wird ein Hyaluronsäure-Präparat in die Gelenkkapsel injiziert. Im Allgemeinen werden mehrere Injektionen in kürzeren Abständen durchgeführt.

Die positiven Effekte stellen sich ein, wenn die Reizung des Gelenks durch die Injektion abgeklungen ist. Auch wenn die injizierte Hyaluronsäure selbst recht schnell wieder abgebaut wird: Die therapeutische Wirkung kann bis zu 12 Monate anhalten. Das liegt daran, dass Hyaluronsäure den Knorpel nicht nur durch verbesserte Qualität der Synovialflüssigkeit schützt, sondern auch seine Regeneration stimuliert. Die besten Ergebnisse werden für Arthrose im Frühstadium erzielt, deren Fortschreiten durch regelmäßige Applikation von Hyaluronsäure oft deutlich verlangsamt wird.

Hyaluronsäure in der ästhetischen Medizin

Neben der kosmetischen Optimierung von Gesichtszügen und der Bekämpfung von Zeichen der Hautalterung hat Hyaluronsäure auch einen Platz in der plastischen Rekonstruktionschirurgie. Hier können Missbildungen korrigiert sowie nach Unfällen, Tumoroperationen oder anderen folgenreichen Eingriffen Körperkonturen neu modelliert und Narben unauffälliger gestaltet werden.

Für den lokalen oder großflächigen Volumenaufbau wird oft das Präparat Macrolane injiziert, ein seit 2008 zugelassenes stabilisiertes Hyaluronsäure-Gel. Die Nebenwirkungen der Injektion des zähen Gels können für einige Tage recht schmerzhaft sein. Davon abgesehen wird die Behandlung in aller Regel gut vertragen. Ihre Wirkung hält etwa ein Jahr an.

Weitere Informationen zu Hyaluronsäure in der Medizin

Medizinische Einsatz von Hyaluronsäure bei Athroseleiden

Belege:

Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis. A.W.Rutjes, P.Jüni, B.R.da Costa, S.Trelle, E.Nüesch und S.Reichenbach. Annals of Internal Medicine (August 2012)

Body Shaping and Volume Restoration: The Role of Hyaluronic Acid. P.Hedén, G.Sellman, M.v.Wachenfeldt, M.Olenius und D.Fagrell. Aesthetic Plastic Surgery (Mai 2009)


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